Document Detail


The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases.
MedLine Citation:
PMID:  15751279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the significance of proteases in interstitial lung diseases, we examined the activity of cathepsins, thrombin, and aminopeptidase in bronchoalveolar lavage (BAL) fluid from patients with these disorders. Significantly increased activities of cathepsin H and aminopeptidase were detected in BAL fluid from patients with idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), chronic eosinophilic pneumonia (CEP) and hypersensitivity pneumonitis (HP). Significantly higher activity of cathepsin B was found in BAL fluid from patients with CEP. The activity of thrombin was significantly higher in patients with IPF and CEP. In patients with IPF, there were significant correlations between neutrophil number and the activity of cathepsin B, cathepsin H or aminopeptidase. In patients with COP and HP, the activity of the proteases was significantly higher in patients with higher number of lymphocytes than in those with lower number of lymphocytes. The present study suggests that the activity of the proteases is a useful marker in activity of the interstitial lung diseases, and may have a role in the pathogenesis of these disorders.
Authors:
Makoto Kimura; Kenji Tani; Junya Miyata; Keiko Sato; Akihito Hayashi; Shinsaku Otsuka; Tomoyuki Urata; Saburo Sone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  52     ISSN:  1343-1420     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aminopeptidases / metabolism
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Case-Control Studies
Cathepsins / metabolism
Female
Humans
Lung Diseases, Interstitial / enzymology*,  pathology
Lymphocytes / pathology
Male
Middle Aged
Peptide Hydrolases / metabolism*
Thrombin / metabolism
Chemical
Reg. No./Substance:
EC 3.4.-/Cathepsins; EC 3.4.-/Peptide Hydrolases; EC 3.4.11.-/Aminopeptidases; EC 3.4.21.5/Thrombin

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