Document Detail


The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients.
MedLine Citation:
PMID:  19411106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P<0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities.
Authors:
Dandan Liu; Zixing Chen; Yongquan Xue; Dingwei Lu; Youning Zhou; Jingxia Gong; Weilin Wu; Jianying Liang; Qinfen Ma; Jinlan Pan; Yafang Wu; Yong Wang; Jun Zhang; Juan Shen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-05-02
Journal Detail:
Title:  Leukemia research     Volume:  33     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-38     Citation Subset:  IM    
Affiliation:
The First Affiliated Hospital of Soochow University, Leukemia Research Division, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, PR China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia, Refractory / pathology*
Bone Marrow Cells / pathology*
Child
Child, Preschool
Chromosome Aberrations*
Diagnosis, Differential
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelodysplastic Syndromes / pathology*
Retrospective Studies
Comments/Corrections
Comment In:
Leuk Res. 2009 Aug;33(8):1019   [PMID:  19303635 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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