| The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the "early" prepolycythemic phase of polycythemia vera and essential thrombocythemia. | |
| | |
MedLine Citation:
|
PMID: 18701405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been suggested that polycythemia vera (PV) could be preceded by an "early" phase of the disease (e-PV), in which the increase in the red cell parameters is lower than required for a PV diagnosis. In this study, we compared the clinicopathologic and molecular features of 17 patients with e-PV with those of 14 patients with essential thrombocythemia (ET) and 19 with PV. The results for e-PV were more similar to those for PV than for ET. In fact, patients with e-PV were characterized by an increase in the red cell parameters, splenomegaly (P<.05), and hepatomegaly (P=.038), together with hypercellular bone marrow due to increased erythropoiesis and granulopoiesis, associated with megakaryocytic hyperplasia, with pleomorphic aggregates (P<.001). The frequency of the JAK2V617F mutation was similar in e-PV (16 cases tested [100%]) and PV (18/19 [95%]) but was significantly lower (7/13 [54%]) in ET (P=.0007). We propose a diagnostic algorithm helpful to distinguish ET from the early prepolycythemic phase of PV. |
| | |
Authors:
|
Umberto Gianelli; Alessandra Iurlo; Claudia Vener; Alessia Moro; Elisa Fermo; Paola Bianchi; Daniela Graziani; Franca Radaelli; Guido Coggi; Silvano Bosari; Giorgio Lambertenghi Deliliers; Alberto Zanella |
Related Documents
:
|
7713595 - Neonatal anemia: pathophysiology and treatment. 3938415 - Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to e... 9590185 - Registry of pregnancy in dialysis patients. 21253175 - Preventive health examinations part ii. 2366135 - Effect of the feeding practices on the establishment of bacterial interactions in the i... 16916305 - Aetiology, risk factors and immediate outcome of bacteriologically confirmed neonatal s... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 130 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-08-14 Completed Date: 2008-09-18 Revised Date: 2012-06-05 |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 336-42 Citation Subset: AIM; IM |
Affiliation:
|
Pathology Unit, Department of Medicine, Surgery, and Odontology, University of Milan, San Paolo Hospital, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Algorithms Bone Marrow / pathology* Diagnosis, Differential Female Humans Janus Kinase 2 / genetics* Male Middle Aged Polycythemia Vera / diagnosis* Retrospective Studies Thrombocythemia, Essential / diagnosis* |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Robust control-based object tracking.
Next Document: Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue micr...