Document Detail

The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the "early" prepolycythemic phase of polycythemia vera and essential thrombocythemia.
MedLine Citation:
PMID:  18701405     Owner:  NLM     Status:  MEDLINE    
It has been suggested that polycythemia vera (PV) could be preceded by an "early" phase of the disease (e-PV), in which the increase in the red cell parameters is lower than required for a PV diagnosis. In this study, we compared the clinicopathologic and molecular features of 17 patients with e-PV with those of 14 patients with essential thrombocythemia (ET) and 19 with PV. The results for e-PV were more similar to those for PV than for ET. In fact, patients with e-PV were characterized by an increase in the red cell parameters, splenomegaly (P<.05), and hepatomegaly (P=.038), together with hypercellular bone marrow due to increased erythropoiesis and granulopoiesis, associated with megakaryocytic hyperplasia, with pleomorphic aggregates (P<.001). The frequency of the JAK2V617F mutation was similar in e-PV (16 cases tested [100%]) and PV (18/19 [95%]) but was significantly lower (7/13 [54%]) in ET (P=.0007). We propose a diagnostic algorithm helpful to distinguish ET from the early prepolycythemic phase of PV.
Umberto Gianelli; Alessandra Iurlo; Claudia Vener; Alessia Moro; Elisa Fermo; Paola Bianchi; Daniela Graziani; Franca Radaelli; Guido Coggi; Silvano Bosari; Giorgio Lambertenghi Deliliers; Alberto Zanella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  130     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-09-18     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-42     Citation Subset:  AIM; IM    
Pathology Unit, Department of Medicine, Surgery, and Odontology, University of Milan, San Paolo Hospital, Milan, Italy.
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MeSH Terms
Aged, 80 and over
Bone Marrow / pathology*
Diagnosis, Differential
Janus Kinase 2 / genetics*
Middle Aged
Polycythemia Vera / diagnosis*
Retrospective Studies
Thrombocythemia, Essential / diagnosis*
Reg. No./Substance:
EC Kinase 2; EC protein, human

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