Document Detail

The significance of Peyer's plaques for intestinal immunity. Animal experimental inferences
MedLine Citation:
PMID:  6339338     Owner:  NLM     Status:  MEDLINE    
The removal of Peyer's patches alters the first line of defence against a known bacterium. Whereas in control animals all reactive cells could be found within the lamina propria of the gut, in rats without Peyer's patches only small amounts of IgA and IgM secreting cells could be detected there. In contrast IgA and IgM secreting cells could be found within mesenteric lymph nodes and spleen. The removal of the Peyer's patches diminishes the reaction of the lamina propria. Therefore other lymphatic structures like mesenteric lymph nodes and spleen get contact with antigenic material and generate E. coli specific immune globulin secreting cells. These cells were able to secrete IgA which was detected within the bile. This compensatory mechanism helps to restore the disturbed balance. The consequence of the systemic reaction against the E. coli must be discussed in view of cross reacting antibodies or the generation of inflammatory cells within the gut.
G Enders; J Seifert
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Fortschritte der Medizin     Volume:  101     ISSN:  0015-8178     ISO Abbreviation:  Fortschr. Med.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984763R     Medline TA:  Fortschr Med     Country:  GERMANY, EAST    
Other Details:
Languages:  ger     Pagination:  113-7     Citation Subset:  IM    
Vernacular Title:
Zur Bedeutung der Peyer'schen Plaques für die Darmimmunität. Tierexperimentelle Hinweise.
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MeSH Terms
Antibody-Producing Cells / immunology
Escherichia coli / immunology
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Intestines / immunology*
Lymph Nodes / cytology
Lymphocytes / immunology
Lymphoid Tissue / immunology*
Peyer's Patches / immunology*
Rats, Inbred Strains
Spleen / cytology
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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