Document Detail

The significance of C-reactive protein in the diagnosis of fetal tachycardia and therapy of chorioamnionitis.
MedLine Citation:
PMID:  16108395     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: [corrected] Pregnant woman with fetal tachycardia have a risk of chorioamnionitis as cause of tachycardia. Different studies have supported or refuted the use of C-reactive protein (CRP) to diagnose chorioamnionitis. The goal of this study was to evaluate serial serum CRP levels for diagnosis of chorioamnionitis. METHODS: The study included 60 woman with chorioamnionitis confirmed after measuring the levels of CRP. Patients were monitored by CRP determination, white blood cell (WBC) count, maternal temperature, maternal and fetal heart rate. RESULTS: Elevated CRP level was present in 93.33% of cases. Fetal tachycardia was present in 91,67 cases, all associated with elevated CRP level. Increased WBC count was present in 63.33%. A statistically significant difference was found in the level of CRP in pregnant women with increased WBC count compared with those without (p < 0.01). CONCLUSION: Elevated C-reactive protein levels were more sensitive than other standard laboratory or clinical tests in predicting chorioamnionitis. Also, recent reports indicate that serial CRP levels during this interval may be useful for monitoring antibiotic treatment.
M Gojnic; A Fazlagic; M Pervulov; S Petkovic; T Mostic; K Jeremic
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  32     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-19     Completed Date:  2005-11-07     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  114-6     Citation Subset:  IM    
Medical Faculty, Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia and Montenegro.
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MeSH Terms
Anti-Bacterial Agents
Biological Markers / blood
C-Reactive Protein / analysis*
Chorioamnionitis / blood,  diagnosis*,  drug therapy*
Cohort Studies
Drug Therapy, Combination
Fetal Diseases / diagnosis,  drug therapy
Gestational Age
Heart Rate, Fetal
Predictive Value of Tests
Pregnancy Complications / blood,  diagnosis*,  drug therapy
Pregnancy Outcome*
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Tachycardia / blood,  diagnosis*
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biological Markers; 9007-41-4/C-Reactive Protein

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