Document Detail


A signalling role for muscle glycogen in the regulation of pace during prolonged exercise.
MedLine Citation:
PMID:  15618337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: In this study we examined the pacing strategy and the end muscle glycogen contents in eight cyclists, once when they were carbohydrate loaded and once when they were non-loaded. METHODS: Cyclists completed 2 hours of cycling at approximately 73% of maximum oxygen consumption, which included five sprints at 100% of peak sustained power output every 20 minutes, followed immediately by a 1 hour time trial. Muscle biopsies were performed before and immediately after exercise, while blood samples were taken during the 2 hour steady state rides and immediately after exercise. RESULTS: Carbohydrate loading improved mean power output during the 1 hour time trial (mean (SEM) 219 (17) v 233 (15) W; p<0.05) and enabled subjects to use significantly more muscle glycogen than during the trial following their normal diet. Significantly, the subjects, kept blind to all feedback except for time, started both time trials at similar workloads ( approximately 30 W), but after 1 minute of cycling, the workload average 14 W higher throughout the loaded compared with the non-loaded time trial. There were no differences in subjects' plasma glucose and lactate concentrations and heart rates in the carbohydrate loaded versus the non-loaded trial. Of the eight subjects, seven improved their time trial performance after carbohydrate loading. Finishing muscle glycogen concentrations in these seven subjects were remarkably similar in both trials (18 (3) v 20 (3) mmol/kg w/w), despite significantly different starting values and time trial performances (36.55 (1.47) v 38.14 (1.27) km/h; p<0.05). The intra-subject coefficient of variation (CV) for end glycogen content in these seven subjects was 10%, compared with an inter-subject CV of 43%. CONCLUSIONS: As seven subjects completed the time trials with the same end exercise muscle glycogen concentrations, diet induced changes in pacing strategies during the time trials in these subjects may have resulted from integrated feedback from the periphery, perhaps from glycogen content in exercising muscles.
Authors:
H G L Rauch; A St Clair Gibson; E V Lambert; T D Noakes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of sports medicine     Volume:  39     ISSN:  1473-0480     ISO Abbreviation:  Br J Sports Med     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-02-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Affiliation:
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Sports Science Institute, Boundary Road, Newlands, Cape Town 7700, South Africa. lrauch@sports.uct.ac.za
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling / physiology*
Biopsy / methods
Blood Glucose / analysis
Dietary Carbohydrates / administration & dosage
Exercise / physiology*
Exercise Test / methods
Glycogen / metabolism*
Heart Rate / physiology
Humans
Lactic Acid / blood
Male
Muscle, Skeletal / metabolism*
Oxygen Consumption / physiology
Physical Endurance / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 50-21-5/Lactic Acid; 9005-79-2/Glycogen
Comments/Corrections

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