Document Detail


FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.
MedLine Citation:
PMID:  21750042     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The epicardium serves as a source of growth factors that regulate myocardial proliferation and as a source of epicardial-derived cells (EPDC), which give rise to interstitial cardiac fibroblasts and perivascular cells. These progenitors populate the compact myocardium to become part of the mature coronary vasculature and fibrous skeleton of the heart. Little is known about the mechanisms that regulate EPDC migration into the myocardium or the functions carried out by these cells once they enter the myocardium. However, it has been proposed that cardiac fibroblasts are important for growth of the heart during late gestation and are a source of homeostatic factors in the adult. Here, we identify a myocardial to epicardial fibroblast growth factor (FGF) signal, mediated by FGF10 and FGFR2b, that is essential for movement of cardiac fibroblasts into the compact myocardium. Inactivation of this signaling pathway results in fewer epicardial derived cells within the compact myocardium, decreased myocardial proliferation and a resulting smaller thin-walled heart.
Authors:
Mónica Vega-Hernández; Attila Kovacs; Stijn De Langhe; David M Ornitz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-09-19     Revised Date:  2013-08-30    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3331-40     Citation Subset:  IM    
Affiliation:
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Cell Proliferation
Cells, Cultured
Fibroblast Growth Factor 10 / genetics,  metabolism*
Fibroblasts / cytology,  physiology*
Gene Expression Regulation, Developmental
Heart / anatomy & histology,  embryology*,  growth & development*
Mice
Mice, Knockout
Myocardium / cytology*
Organogenesis / physiology
Pericardium / cytology,  physiology
Receptor, Fibroblast Growth Factor, Type 2 / genetics,  metabolism*
Signal Transduction / physiology*
Grant Support
ID/Acronym/Agency:
HD049808/HD/NICHD NIH HHS; HL092967/HL/NHLBI NIH HHS; R01 HL092967/HL/NHLBI NIH HHS; R01 HL092967-03/HL/NHLBI NIH HHS; R01 HL092967-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fgf10 protein, mouse; 0/Fibroblast Growth Factor 10; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 2
Comments/Corrections

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