| Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus. | |
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MedLine Citation:
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PMID: 22820325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure. |
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Authors:
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Magdalena M van der Kooi-Pol; Ewoud Reilman; Mark J J B Sibbald; Yanka K Veenstra-Kyuchukova; Thijs R H M Kouwen; Girbe Buist; Jan Maarten van Dijl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-20 |
Journal Detail:
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Title: Applied and environmental microbiology Volume: 78 ISSN: 1098-5336 ISO Abbreviation: Appl. Environ. Microbiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-10 Completed Date: 2013-01-23 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7605801 Medline TA: Appl Environ Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 7124-7 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism* Gene Expression Membrane Proteins / metabolism* Protein Disulfide Reductase (Glutathione) / metabolism* Serine Endopeptidases / metabolism* Staphylococcus aureus / enzymology*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Membrane Proteins; EC 1.8.4.2/Protein Disulfide Reductase (Glutathione); EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.89/type I signal peptidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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