Document Detail

Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus.
MedLine Citation:
PMID:  22820325     Owner:  NLM     Status:  MEDLINE    
Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.
Magdalena M van der Kooi-Pol; Ewoud Reilman; Mark J J B Sibbald; Yanka K Veenstra-Kyuchukova; Thijs R H M Kouwen; Girbe Buist; Jan Maarten van Dijl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-20
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  78     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-01-23     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7124-7     Citation Subset:  IM    
Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
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MeSH Terms
Bacterial Proteins / metabolism*
Gene Expression
Membrane Proteins / metabolism*
Protein Disulfide Reductase (Glutathione) / metabolism*
Serine Endopeptidases / metabolism*
Staphylococcus aureus / enzymology*,  metabolism*
Reg. No./Substance:
0/Bacterial Proteins; 0/Membrane Proteins; EC Disulfide Reductase (Glutathione); EC 3.4.21.-/Serine Endopeptidases; EC I signal peptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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