Document Detail

Persistence on therapy is a major determinant of patient-, physician- and laboratory- reported outcomes in recent-onset rheumatoid arthritis patients.
MedLine Citation:
PMID:  20863447     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate impact of persistence on therapy on sustained major patient-, physician- and laboratory-reported outcomes (PROs, PHYROs and LAROs, respectively) in 112 recent-onset rheumatoid arthritis (RA) patients.
METHODS: At each visit a rheumatologist interviewed patients regarding therapy, morning stiffness and fatigue, scored the 28-joint disease activity score and a visual analogue scale (VAS) and determined acute-phase-reactants. The patients completed the Hispanic version of the Rheumatoid Arthritis Disease Activity Index, the Medical Outcome Short Form 36 (SF-36), the Health Assessment Questionnaire (HAQ), a pain-VAS and an overall-disease activity-VAS. Persistence was defined by self-report through directed interview. Sustained major PROs, PHYROs and LAROs were defined according to cut-offs, when maintained for ≥6 months and until last follow-up. Descriptive statistics, Kaplan-Meier curves and Cox models were used.
RESULTS: Total person-time of receiving therapy was of 375.5 patient-years. From February 2004 to June 2009, 36 (32.1%) patients were persistent. Baseline PROs/PHYROs/LAROs showed active disease and poor health status in both groups, but persistent patients (PP) had significantly lower HAQ (p=0.03) and overall-disease activity-VAS (p=0.01). More PP reached a sustained major SF-36-physical function-score (p=0.02). Persistence was the greatest independent risk factor for sustained major PROs (but absence of fatigue) and PHYROs, (p≤0.04). Time from baseline to major and sustained PROs (excluded absence of fatigue), PHYROs and C-reactive protein were shorter in PP (p≤0.04).
CONCLUSIONS: Persistence was a strong predictor for major and sustained outcomes in early RA. Favourable outcomes appear earlier in persistent than in non-persistent patients.
I Contreras-Yáñez; J Cabiedes; A R Villa; M Rull-Gabayet; V Pascual-Ramos
Related Documents :
9550427 - Tnf and lymphotoxin-alpha polymorphisms associated with common variable immunodeficienc...
9694057 - Corticosteroid prescribing in rheumatoid arthritis and psoriatic arthritis.
7214257 - Leucocyte glutamate dehydrogenase in various hereditary ataxias.
1991217 - The development and use of patient knowledge questionnaire in rheumatoid arthritis.
20189267 - Active surveillance testing and decontamination strategies in intensive care units to r...
12877457 - Occupational rhinitis and bronchial asthma due to artichoke (cynara scolymus).
Publication Detail:
Type:  Journal Article     Date:  2010-10-22
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  28     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  748-51     Citation Subset:  IM    
Department of Immunology and Rheumatology, Universidad Nacional Autónoma de México, México DF, México.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / blood,  drug therapy*,  physiopathology
Blood Sedimentation
C-Reactive Protein / analysis
Disability Evaluation
Health Status
Joints / physiopathology
Medication Adherence*
Middle Aged
Patient Satisfaction*
Quality of Life
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Variability of fatigue during the day in patients with primary Sjögren's syndrome, systemic lupus e...
Next Document:  Active disease requiring TNF-alpha-antagonist therapy can be well discriminated with different ASDAS...