| Is sigmoidoscopy sufficient for evaluating inflammatory status of ulcerative colitis patients? | |
| | |
MedLine Citation:
|
PMID: 21054518 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background and Aims: An adequate range of colonic observations for precise evaluation of inflammation in ulcerative colitis (UC) patients has not been reported. Methods: Retrospective analysis of 545 colonoscopic examinations of UC patients was carried out. Severity of mucosal inflammation was evaluated using the Mayo score of endoscopic index at each location (rectum, sigmoid colon, descending colon, and the oral side of the splenic flexure) in each patient. The colonic site with maximum inflammation was determined for each patient. Results: Of 545 patients, 319 (59%) had maximum inflammation in the rectum, 79 (14%) in the sigmoid colon, 70 (13%) in the descending colon, and 77 (14%) on the oral side of the splenic flexure. Severe inflammatory activity (Mayo 3) was observed more frequently in patients who had maximum activity in the descending colon or the more proximal portion than those who had this in the rectum or sigmoid colon (42% vs 25%, P < 0.0001). The first-attack patients were significantly more frequently found in patients with maximum severity in the descending colon or the oral side of splenic flexure than those with maximum severity in the rectum or sigmoid colon (P = 0.016). Moreover, among 134 patients with no inflammation in the rectum and sigmoid colon, 54 (40%) had inflamed mucosa in the descending colon or the more proximal portion. Conclusions: Sigmoidoscopy is not sufficient for evaluating inflammation in UC patients. In particular, colonoscopy is necessary for first-attack patients and patients who have a discrepancy between rectosigmoid observation and symptoms. |
| | |
Authors:
|
Jun Kato; Motoaki Kuriyama; Sakiko Hiraoka; Kazuhide Yamamoto |
Related Documents
:
|
12471548 - Colonoscopic barotrauma treated by conservative management: role of high-flow oxygen in... 8371728 - Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome ... 21332338 - Urinary umod excretion and chronic kidney disease in gout patients: cross-sectional cas... 7167738 - A quantitative method of estimating inflammation in the rectal mucosa. ii. normal limit... 10442608 - Perineal hemangioma, anorectal malformation, and genital anomaly: a new association? 19811278 - Treatment with dnase i fosters binding to nec pbmc of crp. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: 26 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
|
Languages: eng Pagination: 683-7 Citation Subset: IM |
Copyright Information:
|
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sophocarpine alleviates non-alcoholic steatohepatitis in rats.
Next Document: Impaired postprandial releases/syntheses of ghrelin and PYY(3-36) and blunted responses to exogenous...