Document Detail


The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat.
MedLine Citation:
PMID:  8095466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
Authors:
C Labie; P E Keane; P Soubrié; G Le Fur
Related Documents :
6105206 - Phencyclidine-like discriminative effects of opioids in the rat.
6748366 - Effects of chronic haloperidol and chlordiazepoxide treatment on lateral hypothalamic s...
986946 - Differential attenuation of some effects of haloperidol in rats given scopolamine.
6686676 - Cataleptogenic effect of haloperidol, chlorpromazine and morphine in developing rats.
1552826 - Decreased renin release and constant kallikrein secretion after injection of l-name in ...
7501296 - Interaction of the dopaminergic and serotonergic systems in the rat striatum: effects o...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  231     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  465-7     Citation Subset:  IM    
Affiliation:
Sanofi Recherche, Toulouse, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antipsychotic Agents / pharmacology*
Azepines / pharmacology*
Caudate Nucleus / drug effects*,  metabolism
Dose-Response Relationship, Drug
Haloperidol / pharmacology
Injections, Intraperitoneal
Neurotensin / metabolism*
Nucleus Accumbens / drug effects*,  metabolism
Putamen / drug effects*,  metabolism
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Azepines; 139592-99-7/3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride; 39379-15-2/Neurotensin; 52-86-8/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not affect...
Next Document:  Interactions between U-50,488H and sigma receptor antagonists: EEG, EEG power spectral and behaviora...