Document Detail

The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat.
MedLine Citation:
PMID:  8095466     Owner:  NLM     Status:  MEDLINE    
The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
C Labie; P E Keane; P Soubrié; G Le Fur
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  231     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  465-7     Citation Subset:  IM    
Sanofi Recherche, Toulouse, France.
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MeSH Terms
Antipsychotic Agents / pharmacology*
Azepines / pharmacology*
Caudate Nucleus / drug effects*,  metabolism
Dose-Response Relationship, Drug
Haloperidol / pharmacology
Injections, Intraperitoneal
Neurotensin / metabolism*
Nucleus Accumbens / drug effects*,  metabolism
Putamen / drug effects*,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antipsychotic Agents; 0/Azepines; 139592-99-7/3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride; 39379-15-2/Neurotensin; 52-86-8/Haloperidol

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