Document Detail

The sialagogue response of striatal dopamine receptors to L-dopa is not influenced by castration or chronic estrogen treatment.
MedLine Citation:
PMID:  3955384     Owner:  NLM     Status:  MEDLINE    
The secretory response of salivary glands to L-dopa, elicited by stimulation of dopamine receptors in the striatum and the circling behavior induced by apomorphine in animals bearing a unilateral kainic lesion of the entopeduncular nucleus, was studied in intact and ovariectomized female rats. Castration did not modify the sialagogue response to L-dopa, while the turning behavior was significantly increased. Daily administration of 17-beta-estradiol benzoate during 7 days to ovariectomized rats decreased the circling activity to the level of intact female rats, while the salivary secretion to L-dopa was unaffected. The above findings suggest that the sialagogue response induced by L-dopa may be due to the interaction of this agonist with D1 striatal receptors, whose activity is not influenced by estrogens. However, we cannot rule out any possible alteration in the metabolism and/or presynaptic conversion of L-dopa to dopamine by estrogen treatment. The changes in turning behavior may be attributed to an antidopaminergic effect of estrogens and/or, like L-dopa, to modifications in the metabolism of apomorphine induced by the hormone.
J H Pazo; M Gomez-Gonzales; O R Tumilasci; P O'Donnell; G Murer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  16     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / drug effects
Corpus Striatum / drug effects,  metabolism
Estradiol / pharmacology*
Kainic Acid / pharmacology
Levodopa / pharmacology*
Rats, Inbred Strains
Receptors, Dopamine / drug effects*
Salivary Glands / physiopathology,  secretion*
Time Factors
Reg. No./Substance:
0/Levodopa; 0/Receptors, Dopamine; 487-79-6/Kainic Acid; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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