Document Detail

On the shoulders of giants: a historical perspective of unique experimental methods in mammary gland research.
MedLine Citation:
PMID:  22425744     Owner:  NLM     Status:  MEDLINE    
While most organs undergo development in utero, the mouse mammary gland orchestrates five major developmental stages following birth: pre-puberty, puberty, pregnancy, lactation, and involution. Induced by both local and systemic factors, these five developmental stages transpire with dramatic alterations in glandular morphology and cellular function. As an experimental system, the mammary gland provides remarkable accessibility to processes regulating stem cell function, hormone response, and epithelial-stromal-extracellular matrix interactions. This review will provide a historical perspective of the unique in vitro and in vivo techniques used to study the mammary gland and how these methods have provided valuable insight into the biology of this organ.
Brittni A Smith; Alana L Welm; Bryan E Welm
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-03-09
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  23     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-10-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  583-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 USA.
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MeSH Terms
Cloning, Molecular
Mammary Glands, Animal* / cytology,  metabolism,  transplantation
Stem Cell Transplantation
Stem Cells / cytology
Grant Support
R01 CA140296/CA/NCI NIH HHS; R01 CA143815/CA/NCI NIH HHS; R01CA140296/CA/NCI NIH HHS; R01CA143815/CA/NCI NIH HHS

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