Document Detail


The short-term pulsatile ventricular assist device for postcardiotomy cardiogenic shock: a clinical trial in China.
MedLine Citation:
PMID:  19335414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the recent advances in myocardial protection, surgical techniques, intra-aortic balloon therapy, and maximal pharmacological support, postoperative ventricular dysfunction continues to occur in 0.5-1.0% of all patients undergoing cardiac surgery. Ventricular assist device (VAD) is an important therapeutic adjunct in treating patients with profound ventricular dysfunction with postcardiotomy cardiogenic shock. The purpose of this report was to describe the clinical results with the China-made Luo-Ye VAD as a short-term circulatory support. From May 1998 to December 2006, 17 patients with postcardiotomy cardiogenic shock were supported by the Luo-Ye VAD. Of these patients, 10 were males and seven were females with a mean age of 49.6 years (range 36-68 years). All cases were supported by left VAD (LVAD). Mean duration of support was 46.3 h (range 13-113 h). A criteria of insertion was established to standardize implantation criteria. Among the 17 patients treated with LVAD, eight (47.1%) patients were weaned from support and seven (41.2%) patients were discharged from hospital. Ten (58.8%) patients died while on LVAD support (nine cases) or shortly after weaning (one case). The causes of death in the entire group were cardiac (40%), renal failure (20%), neurologic (10%), sepsis (10%), and multiple organ system failure (20%). The complications were represented by bleeding, renal failure, neurologic event, infection, ventricular arrhythmias, etc. The Luo-Ye VAD functioned well and proved to be useful in patients with postcardiotomy cardiogenic shock. It carries a less-postoperative anticoagulant and a low incidence of VAD-related complications. The survival rate was encouraging in our small cohort of patients.
Authors:
Xue-jun Xiao; Zheng-xiang Luo; Chun-xiu Ye; Rui-xin Fan; Ding-hua Yi; Shang-yi Ji; Ruo-bin Wu; An-heng Cheng; Huan-lei Huang; Yue-heng Wu; Xiao-hua Zhang; Shao-yi Zheng
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  33     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-7     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, China. xiaoxuejun@tom.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticoagulants / therapeutic use
Cardiac Surgical Procedures / adverse effects*
China
Equipment Design
Female
Heart-Assist Devices* / adverse effects
Humans
Male
Middle Aged
Postoperative Complications / mortality
Pulsatile Flow
Shock, Cardiogenic / physiopathology,  therapy*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticoagulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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