Document Detail

The short-term effects of tamsulosin in Japanese men with benign prostatic hyperplasia.
MedLine Citation:
PMID:  10638187     Owner:  NLM     Status:  MEDLINE    
We evaluated the short-term effects of tamsulosin in treating benign prostatic hyperplasia. Twenty-seven patients, aged 57 to 86 years (mean 68.4); complaining of obstructive urinary symptoms who had received no previous treatment for such symptoms were orally administered 0.2 mg of tamsulosin for 4 weeks. Symptoms (total AUA symptom score and AUA symptom subscores) and objective parameters including peak and average flow rate, and post-void residual urine rate were evaluated before and after 1, 2 and 4 weeks of treatment. The mean total AUA symptom score and the mean AUA symptom subscores for incomplete emptying and weak stream were significantly decreased after only 1 week of treatment. The mean AUA symptom subscores for intermittency, urgency and nocturia were significantly decreased after 4 weeks of treatment. The mean AUA symptom subscores for frequency and hesitancy were unchanged after 4 weeks of treatment. The mean peak and average flow rate, and post-void residual urine rate were significantly improved after only 1 week of treatment. In conclusion, tamsulosin improved not only objective parameters but also symptoms only 1 week after the start of treatment.
K Horiuchi; N Tsuboi; T Hattori; K Yoshida; M Akimoto
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nihon Ika Daigaku zasshi     Volume:  66     ISSN:  0048-0444     ISO Abbreviation:  Nippon Ika Daigaku Zasshi     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-23     Completed Date:  2000-02-23     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  7505726     Medline TA:  Nihon Ika Daigaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
Department of Urology, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Administration, Oral
Adrenergic alpha-Antagonists / administration & dosage,  therapeutic use*
Aged, 80 and over
Middle Aged
Prostatic Hyperplasia / drug therapy*
Sulfonamides / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Sulfonamides; 106133-20-4/tamsulosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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