Document Detail


The short-term effect of nifedipine tocolysis on placental, fetal cerebral and atrioventricular Doppler waveforms.
MedLine Citation:
PMID:  15505816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of nifedipine on placental and fetal middle cerebral and atrioventricular Doppler waveforms. METHODS: Doppler waveforms of uterine (UtA), umbilical (UA) and middle cerebral (MCA) arteries and both atrioventricular valves were measured from 21 pregnant women/fetuses prior to and during nifedipine therapy for preterm labor. Maternal and fetal heart rates (FHR), maternal systolic and diastolic blood pressure, the Doppler pulsatility index and systolic/diastolic ratio of the UtA, UA and MCA were measured. The total time velocity integrals (TVI) of tricuspid and mitral valves and their E-wave/A-wave (E/A) TVI ratios were measured. Wilcoxon signed pairs test was used to compare the differences in Doppler parameters before and at 3 h after nifedipine loading up to a maximum dose of 40 mg. RESULTS: Fetal arterial and UtA Doppler parameters were not different before and after nifedipine therapy. Blood flow across the atrioventricular valves and the TVI were equally unaffected by nifedipine. The TVI x FHR product was also unchanged following nifedipine therapy. CONCLUSIONS: In women with otherwise uncomplicated pregnancies, nifedipine loading and tocolysis are generally well tolerated by the mother. Placental and fetal cerebral arterial blood flow, fetal systolic and diastolic cardiac function and downstream distribution of fetal cardiac output are unaffected by nifedipine loading. These results apply to women with unchanged vital parameters. Further studies are necessary to show long-term effects of nifedipine therapy and may help to refine choice of tocolytic agents.
Authors:
S Guclu; U Saygili; E Dogan; N Demir; A A Baschat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  24     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  761-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Dokuz Eylül University School of Medicine, Izmir, Turkey. serkan.guclu@deu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Arteries / ultrasonography
Echocardiography, Doppler
Female
Humans
Nifedipine / therapeutic use*
Obstetric Labor, Premature / prevention & control*,  ultrasonography*
Placenta / ultrasonography
Pregnancy
Pregnancy Trimester, Third
Regional Blood Flow
Statistics, Nonparametric
Tocolytic Agents / therapeutic use*
Ultrasonography, Doppler*
Ultrasonography, Prenatal*
Umbilical Arteries / ultrasonography
Chemical
Reg. No./Substance:
0/Tocolytic Agents; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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