| The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. | |
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MedLine Citation:
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PMID: 1562979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A correlative pathologic and imaging (computed tomography and magnetic resonance imaging) study is reported of a pineal germinoma in a 35-year-old man who died unexpectedly of massive pulmonary embolism on the 8th day during the course of radiation therapy after receiving a total dose of only 1600 cGy. A histologic study of the entire lesion in serial sections revealed no viable tumor cells. The tumor bed was composed of stromal elements with a variable degree of proliferation. The lymphocytic component of the tumor was unaffected by the radiation. This case provided a rare opportunity to show total eradication of tumor cells in a germinoma after a small dose of radiation and supports the notion, based on imaging observations, that histologically proven intracranial pure germinomas may be treated successfully with a much smaller dose of radiation than previously thought. |
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Authors:
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F Aydin; N R Ghatak; K Radie-Keane; J Kinard; S D Land |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer Volume: 69 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-05-21 Completed Date: 1992-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2322-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0017. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology Brain Neoplasms / pathology, radiotherapy* Death Dose-Response Relationship, Radiation Humans Male Pinealoma / pathology, radiotherapy* Pulmonary Embolism Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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