| The short-term effect of atorvastatin on carotid plaque morphology assessed by computer-assisted gray-scale densitometry: a pilot study. | |
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MedLine Citation:
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PMID: 22081003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soft, lipid-containing carotid plaques, which appear echolucent on ultrasound imaging, have been associated with increased risk of ischemic stroke. We sought to investigate the effect of short-term treatment with atorvastatin on the change of carotid plaque echodensity. We treated 40 stroke-free and statin-naive subjects with 80 mg atorvastatin daily for 30 days. Computer assisted gray-scale densitometry (GSD) index was calculated at baseline and 30 days after treatment from the normalized plaque images. A multiple logistic regression was used to assess the effect modification of low-density lipoprotein (LDL) cholesterol on plaque stabilization after adjusting for age, sex, and smoking. The average number of carotid plaques at baseline was 2 (range: 0-5; 27 subjects with carotid plaque) and did not change 30 days following atorvastatin treatment. The mean GSD index significantly increased from 73±16 (range: 1-125) at baseline to 89±15 (range: 1-137) at 30 days after treatment (P<0.05). The adjusted odds ratio for the positive GSD plaque index change (vs. no change or decreased gray-scale median (GSM) index) was 1.71 (95% confidence interval: 1.1-7.6, P<0.01). In conclusion, we observed decreased echolucency (increased echodensity) of carotid artery plaques after short-term treatment with atorvastatin. |
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Authors:
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David Della-Morte; Issam Moussa; Mitchell S Elkind; Ralph L Sacco; Tatjana Rundek |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 33 ISSN: 1743-1328 ISO Abbreviation: Neurol. Res. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: 2012-04-04 Revised Date: 2012-05-17 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 991-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carotid Stenosis / drug therapy*, ultrasonography* Cholesterol, LDL / blood Densitometry / methods Female Heptanoic Acids / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Image Interpretation, Computer-Assisted / methods* Male Pilot Projects Pyrroles / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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K24 NS062737/NS/NINDS NIH HHS; K24 NS062737-01A2/NS/NINDS NIH HHS; R01 NS065114/NS/NINDS NIH HHS; R37 NS 29993/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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