Document Detail

The sheep as a knee osteoarthritis model: early cartilage changes after meniscus injury and repair.
MedLine Citation:
PMID:  17988437     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to analyse cartilage changes after traumatic meniscal lesions and to provide a detailed description of the model used with a view to reducing the number of animals used in future studies. The sheep's knee was chosen, as ovine biomechanics are similar to that of humans. In two groups of 10 animals each, a radial tear in the medial meniscus was either sutured with polydioxanone (PDS) or left untreated (sham-operated). Half of the animals in each group were sacrificed after six months, the other half after one year. The time periods to achieve weight bearing, meniscus healing, joint effusion (magnetic resonance imaging scan) and knee cartilage in the medial, lateral and patellofemoral compartments were evaluated in comparison to the opposite knee (control). Osteoarthritis (OA) was assessed by a modified Outerbridge classification and confirmed by scanning electron microscopy. Only one sutured meniscus remained completely adapted. In all other meniscus lesions, the rupture healed with a scar. In the PDS and sham-operated groups, OA was significantly higher in the medial knee compartment than in the lateral compartment and in controls (P < 0.001). In the operated groups, joint effusion was higher in the right hindlimb knee than in the normal left hindlimb knee (control) after six and 12 months (P < 0.001). Non-treated, displaced and even adapted sutured radial ovine meniscus tears produced intense OA within less than six months. Therefore, this animal model is suitable for assessment of new therapeutic regimens in meniscal surgery.
C Burger; M Mueller; P Wlodarczyk; H Goost; R H Tolba; C Rangger; K Kabir; O Weber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  41     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  420-31     Citation Subset:  IM    
Department of Trauma Surgery, University of Bonn Medical Center, Sigmund Freud Str 25, D-53127 Bonn, Germany. christof.burger@ukb.uni-bon
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MeSH Terms
Body Weight
Disease Models, Animal*
Menisci, Tibial / injuries,  pathology*,  surgery
Osteoarthritis, Knee / pathology*
Wound Healing

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