Document Detail


The shear stress of busting blood clots.
MedLine Citation:
PMID:  23034026     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Systemic delivery of tissue-type plasminogen activator (t-PA) to dissolve a thrombus after a heart attack or stroke is accompanied by the risk of hemorrhage. A recent study shows the use of nanoaggregates to target t-PA to the thrombus in mouse models of mesenteric injury and pulmonary embolism.
Authors:
David M Wootton; B Rita Alevriadou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1361-3     Citation Subset:  AIM; IM    
Affiliation:
From the Department of Mechanical Engineering and the Maurice Kanbar Center for Biomedical Engineering, the Cooper Union for the Advancement of Science and Art, New York (D.M.W.); and the Departments of Biomedical Engineering and Internal Medicine (Cardiovascular Medicine) and the Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus (B.R.A.).
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