Document Detail

Maternal/paternal sharing of DQ-Alpha type II histocompatibility antigens not associated with pregnancy outcome following in vitro fertilization (IVF)-embryo transfer (ET).
MedLine Citation:
PMID:  11530859     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if maternal/paternal sharing of DQ alpha major histocompatibility (MHC) type II antigens is associated with reduced pregnancy and implantation rates following in vitro fertilization-embryo transfer (IVF-ET). METHODS: Prospective study with type II MHC DQ alpha alleles detected by polymerase chain reaction (PCR) technology using Perkin Elmer Amyli-type HLA DQ alpha PCR amplification and typing kit. The tests were only performed on patients having their first IVF cycle. RESULTS: No difference was found in clinical pregnancy rates per transfer between those couples sharing DQ alpha I alleles and those who did not (43.7% vs 40%). There were no spontaneous abortions in the group sharing DQ alpha I alleles. CONCLUSION: Maternal/paternal sharing of DQ alpha I antigens does not reduce fecundity following IVF-ET.
J H Check; J K Choe; L Ubelacker; A DiAntonio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  28     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-03     Completed Date:  2002-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  142-3     Citation Subset:  IM    
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
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MeSH Terms
Embryo Transfer*
Fertilization in Vitro*
HLA-DQ Antigens*
Infertility / immunology
Pregnancy Outcome*
Reg. No./Substance:
0/HLA-DQ Antigens

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