| Is sexual contact a major mode of hepatitis C virus transmission? | |
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MedLine Citation:
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PMID: 20635398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medical opinion varies considerably regarding the transmission of hepatitis C virus (HCV) through sexual contact. Based on the study design, representativeness of the study population, and the methods used for case ascertainment, we analyzed 80 qualifying reports regarding the evidence for or against sexual transmission. Regarding heterosexual transmission, the weight of evidence is that there is no increased risk of sexual transmission of HCV among heterosexual couples in regular relationships. This risk increases among persons with multiple sexual partners (adjusted odds ratio [aOR] 2.2-2.9), but this association may be confounded by increased likelihood of injection drug use with increased number of partners. There appears to be a real increased risk for women coinfected with human immunodeficiency virus (HIV) or other sexually transmitted infections (aOR 3.3-3.9) and especially for HIV-infected gay men who are having sex with one another compared with HIV-uninfected men (aOR 4.1-5.7). HIV-infected gay men increase their risk of such transmission in association with practices that lead to mucosal trauma (multiple sexual partners, fisting, use of sex toys) and the presence of genital ulcerative disease. CONCLUSION: This review should inform, and not distract from, recommendations to reduce the risk of HCV transmission. Health care providers need to pay special attention to sexual transmission of HCV among HIV-infected individuals. |
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Authors:
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Rania A Tohme; Scott D Holmberg |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 52 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2010-10-18 Revised Date: 2011-08-15 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1497-505 Citation Subset: IM |
Affiliation:
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Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, USA. rtohme@cdc.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female HIV Infections / complications* Hepacivirus Hepatitis C / complications, transmission* Homosexuality, Male Humans Male Sexual Behavior* Sexual Partners Sexually Transmitted Diseases / transmission* |
| Comments/Corrections | |
Comment In:
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Hepatology. 2011 Jul;54(1):379
[PMID:
21462231
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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