Document Detail


A sex-specific relationship between capillary density and anaerobic threshold.
MedLine Citation:
PMID:  19164774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although both capillary density and peak oxygen consumption (Vo(2)) improve with exercise training, it is difficult to find a relationship between these two measures. It has been suggested that peak Vo(2) may be more related to central hemodynamics than to the oxidative potential of skeletal muscle, which may account for this observation. We hypothesized that change in a measure of submaximal performance, anaerobic threshold, might be related to change in skeletal muscle capillary density, a marker of oxidative potential in muscle, with training. Due to baseline differences among these variables, we also hypothesized that relationships might be sex specific. A group of 21 subjects completed an inactive control period, whereas 28 subjects (17 men and 11 women) participated in a 6-mo high-intensity exercise program. All subjects were sedentary, overweight, and dyslipidemic. Potential relationships were assessed between change in capillary density with both change in Vo(2) at peak and at anaerobic threshold with exercise training. All variables and relationships were assessed for sex-specific effects. Change in peak Vo(2) was not related to change in capillary density after exercise training in either sex. Men had a positive correlation between change in Vo(2) at anaerobic threshold and change in capillary density with exercise training (r = 0.635; P < 0.01), whereas women had an inverse relationship (r = -0.636; P < 0.05) between the change in these variables. These findings suggest that, although enhanced capillary density is associated with training-induced improvements in submaximal performance in men, this relationship is different in women.
Authors:
Jennifer L Robbins; Brian D Duscha; Daniel R Bensimhon; Karlman Wasserman; James E Hansen; Joseph A Houmard; Brian H Annex; William E Kraus
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-01-22
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  106     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-05-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1181-6     Citation Subset:  IM    
Affiliation:
Duke University Medical Center, Division of Cardiology, Durham, North Carolina 27710, USA. j.robbins@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anaerobic Threshold / physiology*
Body Mass Index
Capillaries / anatomy & histology*,  physiology*
Dyslipidemias / physiopathology
Female
Humans
Male
Middle Aged
Muscle, Skeletal / blood supply*,  physiology
Overweight / physiopathology
Oxygen Consumption / physiology
Physical Fitness / physiology
Regional Blood Flow / physiology
Sex Characteristics
Grant Support
ID/Acronym/Agency:
R1 HL-57354/HL/NHLBI NIH HHS
Comments/Corrections

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