| Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006. | |
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MedLine Citation:
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PMID: 22000606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among adolescents, uric acid is associated with insulin resistance, hypertension, and the metabolic syndrome (MetS); and in adults, high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. The objective was to determine whether the relationship of uric acid with MetS varies in adolescents by race/ethnicity and sex. We used linear regression to evaluate associations between uric acid and other MetS-associated clinical and laboratory measures among 3296 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12 to 19 years participating in the National Health and Nutrition Evaluation Survey (1999-2006). Overall, non-Hispanic white males and females had the highest uric acid levels among the 3 racial/ethnic groups. In each racial/ethnic group, there were higher uric acid levels for those adolescents with vs without MetS. However, the extent of the MetS-related increase in uric acid level varied by race and sex. Among males, MetS was associated with the greatest increases in uric acid among non-Hispanic whites. However, among females the MetS-related increase in uric acid was greater among non-Hispanic blacks and Hispanics. Non-Hispanic white females exhibited the lowest degrees of correlation between levels of uric acid and MetS-associated variables. Uric acid levels did not correlate with insulin levels in non-Hispanic white females. These data suggest that the relationship between uric acid and MetS varies by race/ethnicity and sex. In particular, non-Hispanic white males exhibit a strong relationship and non-Hispanic white females exhibit a relatively poor correlation between uric acid and MetS-related factors. These data may have implications for the use of uric acid as a marker of future risk among adolescents. |
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Authors:
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Mark D DeBoer; Lili Dong; Matthew J Gurka |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-13 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 61 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-19 Completed Date: 2012-07-18 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 554-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA 22908, USA. deboer@virginia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent African Americans Anthropometry Blood Glucose / metabolism Blood Pressure / physiology Child Cholesterol / blood European Continental Ancestry Group Female Hispanic Americans Humans Male Metabolic Syndrome X / epidemiology, ethnology*, metabolism* Nutrition Surveys Prevalence Statistics, Nonparametric Triglycerides / blood United States / epidemiology Uric Acid / blood, metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R21DK085363/DK/NIDDK NIH HHS; 5K08HD060739-02/HD/NICHD NIH HHS; K08 HD060739-02/HD/NICHD NIH HHS; K08 HD060739-03/HD/NICHD NIH HHS; R21 DK085363-01A1/DK/NIDDK NIH HHS; R21 DK085363-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol; 69-93-2/Uric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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