Document Detail

Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006.
MedLine Citation:
PMID:  22000606     Owner:  NLM     Status:  MEDLINE    
Among adolescents, uric acid is associated with insulin resistance, hypertension, and the metabolic syndrome (MetS); and in adults, high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. The objective was to determine whether the relationship of uric acid with MetS varies in adolescents by race/ethnicity and sex. We used linear regression to evaluate associations between uric acid and other MetS-associated clinical and laboratory measures among 3296 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12 to 19 years participating in the National Health and Nutrition Evaluation Survey (1999-2006). Overall, non-Hispanic white males and females had the highest uric acid levels among the 3 racial/ethnic groups. In each racial/ethnic group, there were higher uric acid levels for those adolescents with vs without MetS. However, the extent of the MetS-related increase in uric acid level varied by race and sex. Among males, MetS was associated with the greatest increases in uric acid among non-Hispanic whites. However, among females the MetS-related increase in uric acid was greater among non-Hispanic blacks and Hispanics. Non-Hispanic white females exhibited the lowest degrees of correlation between levels of uric acid and MetS-associated variables. Uric acid levels did not correlate with insulin levels in non-Hispanic white females. These data suggest that the relationship between uric acid and MetS varies by race/ethnicity and sex. In particular, non-Hispanic white males exhibit a strong relationship and non-Hispanic white females exhibit a relatively poor correlation between uric acid and MetS-related factors. These data may have implications for the use of uric acid as a marker of future risk among adolescents.
Mark D DeBoer; Lili Dong; Matthew J Gurka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-13
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  61     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-07-18     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
African Americans
Blood Glucose / metabolism
Blood Pressure / physiology
Cholesterol / blood
European Continental Ancestry Group
Hispanic Americans
Metabolic Syndrome X / epidemiology,  ethnology*,  metabolism*
Nutrition Surveys
Statistics, Nonparametric
Triglycerides / blood
United States / epidemiology
Uric Acid / blood,  metabolism*
Young Adult
Grant Support
1R21DK085363/DK/NIDDK NIH HHS; 5K08HD060739-02/HD/NICHD NIH HHS; K08 HD060739/HD/NICHD NIH HHS; K08 HD060739-02/HD/NICHD NIH HHS; K08 HD060739-03/HD/NICHD NIH HHS; R21 DK085363/DK/NIDDK NIH HHS; R21 DK085363-01A1/DK/NIDDK NIH HHS; R21 DK085363-02/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 268B43MJ25/Uric Acid; 97C5T2UQ7J/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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