| A sex difference in the effects of oral codeine and promethazine on the ventilatory response to carbon dioxide in human volunteers. | |
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MedLine Citation:
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PMID: 7356904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Interactions between codeine and promethazine have been studied in male and female volunteers, measuring ventilation, end tidal PCO2, ventilatory response to CO2, pulse and blood pressure. 2 The effects of codeine on the above measurements have been compared in subjects who habitually smoke cigarettes and non smoking subjects. 3 Codeine displaced the ventilatory response to CO2 to the right and increased end tidal PCO2 in female subjects but not in males. 4 Promethazine plus codeine displaced the ventilatory response to CO2 to the right in male subjects but tended to reduce the response to codeine in females. 5 The slope of the ventilatory response to CO2 was significantly steeper in smokers and codeine caused significant reductions in slope in these subjects. |
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Authors:
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B J Pleuvry; S E Maddison |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 9 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 159-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Carbon Dioxide / pharmacology Codeine / pharmacology* Female Heart Rate / drug effects Humans Male Middle Aged Promethazine / pharmacology* Respiration / drug effects* Sex Factors Smoking / metabolism |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 60-87-7/Promethazine; 76-57-3/Codeine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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