| The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. | |
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MedLine Citation:
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PMID: 15579750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 100 patients with hypopituitarism and 80 sex- and age-matched healthy subjects, we correlated the severity of cardiac impairment to the severity of GH deficiency (GHD). By the GH peak after arginine plus GHRH test (normal > 16.5 microg/liter), the patients were classified as severe GHD (n = 56), partial GHD (n = 27), and non-GHD (n = 17). Compared with controls, decreased left ventricular ejection fraction at rest was found only in severe GHD patients (55.0 +/- 8.8 vs. 63.4 +/- 4.5%, P < 0.001); decreased left ventricular ejection fraction response on effort in severe (-4.6 +/- 17.4 vs. 15.2 +/- 9.1%, P < 0.001) and partial GHD patients (3.6 +/- 6.6 vs. 14.6 +/- 8.3%, P < 0.001); decreased diastolic filling at rest in severe (2.53 +/- 0.68 vs. 3.01 +/- 0.48 end-diastolic volume per second, P < 0.001) and partial GHD (2.61 +/- 0.45 vs. 2.89 +/- 0.54 end-diastolic volume per second, P = 0.004) patients; and decreased exercise duration and capacity in all the patient groups. A normal systolic performance on effort was found in 21.4% of severe GHD, 55.6% of partial GHD, all non-GHD, and 93.7% of controls. A normal diastolic filling at rest was found in 57.1% of severe GHD, 74.1% of partial GHD, 76.5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHD hypopituitary patients. |
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Authors:
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Annamaria Colao; Carolina Di Somma; Alberto Cuocolo; Mariagiovanna Filippella; Francesca Rota; Wanda Acampa; Silvia Savastano; Marco Salvatore; Gaetano Lombardi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 89 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-06 Completed Date: 2005-02-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 5998-6004 Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Napoli, Italy. colao@unina.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arginine / diagnostic use Case-Control Studies Coronary Circulation Diastole Exercise Test Female Growth Hormone-Releasing Hormone / diagnostic use Heart Diseases / diagnosis, etiology*, physiopathology* Hemodynamics Human Growth Hormone / deficiency* Humans Hypopituitarism / complications* Linear Models Male Metabolic Diseases / diagnosis, etiology*, physiopathology* Middle Aged Severity of Illness Index Stroke Volume Systole Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone; 74-79-3/Arginine; 9034-39-3/Growth Hormone-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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