Document Detail

The seven countries study in Japan. Twenty-five-year experience in cardiovascular and all-causes deaths.
MedLine Citation:
PMID:  7596038     Owner:  NLM     Status:  MEDLINE    
Within the Seven Countries Study two Japanese cohorts of men aged 40-59 were enrolled, one from the farming village of Tanushimaru (n = 508) and the other from the fishing village of Ushibuka (n = 502), both located in Kyushu. Cardiovascular risk factors were measured at entry and 10 years later in the survivors. The 25-year death rate for all causes was 30% higher in Ushibuka than in Tanushimaru (p < 0.001) and higher also from specific causes except for violence. Baseline differences in the levels of age, blood pressure, serum cholesterol, smoking habits, body mass index and heart rate explained only 19% of the difference in all-cause mortality between the two towns. Multivariate models from data of the pooled cohorts showed that age was a significant predictor of coronary heart disease, stroke, cancer, all other causes and all-cause mortality. Cigarette smoking predicted coronary heart disease, cancer and all-cause mortality. Systolic blood pressure predicted coronary heart disease, stroke and all-cause mortality. Serum cholesterol, body mass index and heart rate predicted none of these five causes of death. Changes in systolic blood pressure during the first 10 years of follow-up were directly related to deaths between 10 and 25 years of follow-up, significantly improving the predictive power of the multivariate model. Changes in the other risk factors did not contribute, however, to improved prediction.
H Toshima; Y Koga; A Menotti; A Keys; H Blackburn; D R Jacobs; F Seccareccia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  36     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-28     Completed Date:  1995-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  179-89     Citation Subset:  IM    
Kurume University Hospital Medical Center, Japan.
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MeSH Terms
Cardiovascular Diseases / mortality*
Cohort Studies
Japan / epidemiology
Logistic Models
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Risk Factors
Survival Analysis

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