| Is serum troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia? | |
| | |
MedLine Citation:
|
PMID: 17429901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To assess the correlation of echocardiographic signs of myocardial damage to serum cardiac troponin T (cTnT) concentrations in newborn infants with perinatal asphyxia. METHODS: Electocardiograms (ECG) and echocardiograms (Echo) were obtained during the first 24 h of life from 29 asphyxiated and 30 control infants and correlated with cTnT concentrations. The echocardiographic parameters included systolic ventricular performance, preload, afterload, diastolic function, stroke volume (SV), left ventricular output (LVO), hyperechogenity of the papillary muscles and insufficiency of the atrioventricular valves. RESULTS: LVO and SV were lower but CTnT were significantly higher in asphyxiated than in control infants: 0.15 (010-0.23) vs. 0.05 (0.02-0.13), p < 0.001). Asphyxiated infants with signs of myocardial damage were associated with significantly higher cTnT than those without, 0.20 (0.11-0.28) and 0.11 (0.05-0.14 ug/L), p = 0.04. CONCLUSION: Cardiac troponin may prove to be valuable in evaluating myocardial damage in birth asphyxia. However, the degree of prematurity may complicate the assessment. |
| | |
Authors:
|
S Costa; E Zecca; G De Rosa; D De Luca; G Barbato; M Pardeo; C Romagnoli |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 96 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-04-12 Completed Date: 2007-05-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
|
Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
|
Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy. simocosta@yahoo.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asphyxia Neonatorum
/
blood*,
complications*,
physiopathology Biological Markers / blood Cardiac Output / physiology Case-Control Studies Echocardiography Electrocardiography Humans Infant, Newborn Myocardial Ischemia / blood*, diagnosis, etiology* Predictive Value of Tests Prospective Studies Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Troponin T |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Performance of neonatal ventilators in volume targeted ventilation mode.
Next Document: Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fat...