| The serotonin hypothesis of pulmonary hypertension revisited. | |
| | |
MedLine Citation:
|
PMID: 20204739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. Both of these drugs are serotonin transporter (SERT) substrates and indirect serotinergic agonists. There is now a wealth of evidence to support a role for serotonin in the pathobiology of PAH. Synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (TPH1). Serotonin then acts at the 5-HT(1B) receptor and the SERT to mediate constriction and proliferation of pulmonary artery smooth muscle cells. Downstream signalling molecules which play a role in serotonin-induced constriction and proliferation include reactive oxygen species (ROS), Rho-kinase (ROCK) p38 and extracellular signal-regulated kinase (ERK). There is also evidence to suggest that serotonin may interact with the bone morphogenetic receptor type II (BMPRII) to provide a 'second hit' risk factor for PAH. |
| | |
Authors:
|
Margaret R Maclean; Yvonne Dempsie |
Related Documents
:
|
697189 - Restrictive ventilatory defect in a patient with primary pulmonary hypertension. 20704929 - Mechanism of disease: pulmonary hypertension. 10993799 - Liposome-induced pulmonary hypertension: properties and mechanism of a complement-media... 20042709 - Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endot... 8083939 - Estimation of pulmonary artery pressure in patients with primary pulmonary hypertension... 445719 - The extraction of circulating catecholamines by the lungs in normal man and in patients... 18662909 - Endovascular repair of a ruptured internal iliac arterial aneurysm with a novel applica... 19263359 - Crossed wernicke's aphasia after aneurysmal subarachnoid hemorrhage: a case report. 7583539 - Angiotensin ii increases cgmp content via endothelial angiotensin ii at1 subtype recept... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 661 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-03-05 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 309-22 Citation Subset: IM |
Affiliation:
|
Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK. m.maclean@bio.gla.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Appetite Depressants / adverse effects, metabolism Bone Morphogenetic Protein Receptors, Type II / genetics, metabolism Dexfenfluramine / adverse effects, metabolism Endothelial Cells / cytology, metabolism Humans Hypertension, Pulmonary / chemically induced, physiopathology* Lung / blood supply, metabolism, pathology Receptors, Serotonin / metabolism Serotonin / metabolism* Serotonin Agonists / adverse effects, metabolism Serotonin Plasma Membrane Transport Proteins / metabolism Signal Transduction / physiology Vasoconstriction / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Appetite Depressants; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Serotonin Plasma Membrane Transport Proteins; 3239-44-9/Dexfenfluramine; 50-67-9/Serotonin; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rho kinase-mediated vasoconstriction in pulmonary hypertension.
Next Document: Impaired vascular endothelial growth factor signaling in the pathogenesis of neonatal pulmonary vasc...