Document Detail


The seroprevalence of antibodies to toxoplasma gondii in domestic goats in Uganda.
MedLine Citation:
PMID:  10913763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Only limited epidemiological information is available on the seroprevalence of Toxoplasma gondii in domestic livestock in sub-Saharan Africa. In Uganda, goats are important to the local economy and are also popular food animals. A high incidence of T. gondii infection in goats would have implications both for animal production and for public health, but no data is available on Toxoplasma infection in these animals. In this study we estimated the seroprevalence of antibodies against T. gondii in goats located in both urban and rural environments and from different geographical regions within Uganda. Goat sera were collected using a random, two-stage clustering method. Of 784 samples analysed by antibody-ELISA from various districts in Uganda, 240 tested positive. The combined (cluster-adjusted) seroprevalence was 0.31 (31%) (95% confidence intervals 0.28, 0.34) indicating a substantial level of infection in these regions. Seroprevalence was significantly higher in goats from urban locations. A strong positive relationship between age and seroprevalence was demonstrated and a mathematical model based on continuous exposure proved generally accurate in predicting seroprevalence. Farm environments were identified as being suitable for oocyst survival and transmission, and the reported incidence of caprine abortion was high. The importance of toxoplasmosis to goat production in Uganda has yet to be determined, but the high seroprevalence detected in this study suggests that it may have a significant impact and that the consumption of goat meat may play a role in zoonotic transmission to humans.
Authors:
A Bisson; S Maley; C M Rubaire-Akiiki; J M Wastling
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta tropica     Volume:  76     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Affiliation:
Centre for Tropical Veterinary Medicine, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Protozoan / blood*
Enzyme-Linked Immunosorbent Assay / veterinary
Female
Goats / blood,  parasitology*
Male
Rural Health
Seroepidemiologic Studies
Toxoplasma / immunology*
Toxoplasmosis, Animal / epidemiology
Uganda / epidemiology
Urban Health
Zoonoses / epidemiology
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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