Document Detail


The serologic response of patients with stage II melanoma to allogeneic melanoma cell vaccines.
MedLine Citation:
PMID:  4052966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventeen patients with Stage II malignant melanoma were treated with vaccines prepared from three allogeneic melanoma cell lines in an attempt to induce a humoral immune response against melanoma cell surface antigens. The patients were free of detectable melanoma at the time of vaccination. Vaccines were prepared from three melanoma cell lines that expressed highly restricted melanocyte differentiation antigens. One of these cell lines also expressed an antigen found only on this particular line. The antigens were initially identified by antibodies in autologous serum; they were thus known to be recognized by the human immune system. In addition, two of the cell lines expressed HLA-A, -B, -C, and -DR antigens; no HLA antigens were detectable on the third line. The vaccines were administered sequentially by subcutaneous injection, mixed with bacillus Calmette-Guerin (BCG) or Corynebacterium parvum. The patients' sera were tested for antibodies against cell surface antigens of the vaccine cells in protein A assays and immune adherence assays, and the specificity of observed reactions was defined by absorption tests. Antibodies against alloantigens of the vaccine cells developed in 16 patients and in 15 patients, against antigens related to fetal calf serum in the culture medium. The magnitude of the antibody response to alloantigens varied considerably, with no difference between patients who received BCG or C. parvum with their vaccines. Antibodies against the restricted melanocyte differentiation antigens or the unique melanoma antigen expressed by the vaccine cells were not detected.
Authors:
P O Livingston; K Kaelin; C M Pinsky; H F Oettgen; L J Old
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  56     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-11     Completed Date:  1985-12-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2194-200     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Neoplasm / analysis
Antibody Formation
Antigens, Neoplasm
BCG Vaccine / administration & dosage
Bacterial Vaccines / administration & dosage
Cell Line
Female
HLA Antigens / analysis
Humans
Immune Adherence Reaction
Isoantibodies / analysis
Male
Melanoma / immunology*,  mortality,  therapy
Middle Aged
Neoplasm Proteins / immunology*
Propionibacterium acnes / immunology
Staphylococcal Protein A / analysis
Vaccination*
Vaccines / administration & dosage*
Grant Support
ID/Acronym/Agency:
CA-08748/CA/NCI NIH HHS; CA-19267/CA/NCI NIH HHS; CA-28696/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/BCG Vaccine; 0/Bacterial Vaccines; 0/HLA Antigens; 0/Isoantibodies; 0/Neoplasm Proteins; 0/Staphylococcal Protein A; 0/Vaccines; 0/melanoma-specific antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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