Document Detail

A serologic method for the detection of Corynebacterium pseudotuberculosis infections in horses.
MedLine Citation:
PMID:  639519     Owner:  NLM     Status:  MEDLINE    
A serologic technique useful for detecting antibodies formed in horses in response to infection with Corynebacterium pseudotuberculosis is described. The test relies on the ability of C. pseudotuberculosis toxin to produce a wide zone of hemolysis when applied to erythrocytes previously treated with a sterile filtrate of Corynebacterium equi broth culture. The synergistic hemolytic activity can be neutralized by anti-C. pseudotuberculosis serum. This test was used to analyze sera from 616 horses for the presence of C. pseudotuberculosis antitoxin. Of 177 animals (see Table 2) found positive, there were 34 horses with bacteriologically confirmed, active infections and 18 with active but unconfirmed infections. In addition, 13 animals had a history of having had the disease and 112 had no history or evidence of having had the infection. The other 439 horses had negative titers. Statistical treatments confirmed the value of the test as an epidemiological tool but precluded using only titers for the diagnosis of active clinical disease.
H D Knight
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Cornell veterinarian     Volume:  68     ISSN:  0010-8901     ISO Abbreviation:  Cornell Vet     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0074245     Medline TA:  Cornell Vet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-37     Citation Subset:  IM    
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MeSH Terms
Antitoxins / isolation & purification
Corynebacterium / analysis,  immunology
Corynebacterium Infections / diagnosis,  veterinary*
Horse Diseases / diagnosis*
Neutralization Tests / methods
Toxins, Biological / isolation & purification
Reg. No./Substance:
0/Antitoxins; 0/Toxins, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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