| The serine protease from rat liver and hepatoma 8999. Location and role in mitochondrial protein degradation. | |
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MedLine Citation:
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PMID: 209014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Hepatoma 8999 showed extremely high activity of serine protease, but similar activities of other lysosomal proteases to those of normal rat liver. 2. Serine protease from rat liver formed a single immunoprecipitation band against antiserum to purified protease from hepatoma 8999. 3. The serine proteases in rat liver and hepatoma 8999 were restricted to the inner membranes of the mitochondrial fraction. 4. Polyacrylamide gel electrophoresis with sodium dodecylsulfate showed that hepatoma 8999 mitochondria contained less of the slowest moving protein component than rat liver mitochondrial protein. This component was found to be the best substrate for mitochondrial serine protease in both liver and hepatoma 8999. 5. The role of serine protease in mitochondrial protein degradation is discussed on the basis of these results. |
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Authors:
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Y Banno; H P Morris; N Katunuma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biochemistry Volume: 83 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 1978 Jun |
Date Detail:
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Created Date: 1978-09-15 Completed Date: 1978-09-15 Revised Date: 2007-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1545-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / enzymology* Cell Fractionation Immunodiffusion Kinetics Liver Neoplasms / enzymology* Mitochondria / enzymology* Mitochondria, Liver / enzymology* Neoplasm Proteins Neoplasms, Experimental / enzymology Peptide Hydrolases / metabolism* Proteins Rats Serine |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Proteins; 56-45-1/Serine; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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