Document Detail

A serial study of platelet reactivity throughout the first six months after myocardial infarction: its modification by sulphinpyrazone.
MedLine Citation:
PMID:  3118351     Owner:  NLM     Status:  MEDLINE    
Platelet reactivity was studied immediately after and throughout the first 6 months following myocardial infarction. Its modification by sulphinpyrazone was observed. Out of 65 consecutive patients admitted to the coronary care unit, ten did not meet the protocol criteria. Fifty five received either placebo or sulphinpyrazone in a double-blind trial for 6 months, treatment being started within 6 days of infarction. Forty four patients completed the study (19 on placebo and 25 on sulphinpyrazone). An additional ten patients commenced treatment within one day of infarction and were studied daily for one week. Platelet hyper-reactivity was demonstrable in all patients at presentation and persisted throughout the 6 months in the control group. This effect was reversed by sulphinpyrazone, the modification of reactivity being established by the third day of treatment.
M M Kubik; S G Richardson
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  63     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-12-02     Completed Date:  1987-12-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Department of Medicine, Burton Road Hospital, West Midlands, U.K.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology
Blood Platelets / drug effects,  physiology*
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Myocardial Infarction / blood,  drug therapy*
Platelet Aggregation / drug effects
Platelet Count
Sulfinpyrazone / therapeutic use*
Reg. No./Substance:
0/Arachidonic Acids; 506-32-1/Arachidonic Acid; 57-96-5/Sulfinpyrazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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