| A serial study of platelet reactivity throughout the first six months after myocardial infarction: its modification by sulphinpyrazone. | |
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MedLine Citation:
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PMID: 3118351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Platelet reactivity was studied immediately after and throughout the first 6 months following myocardial infarction. Its modification by sulphinpyrazone was observed. Out of 65 consecutive patients admitted to the coronary care unit, ten did not meet the protocol criteria. Fifty five received either placebo or sulphinpyrazone in a double-blind trial for 6 months, treatment being started within 6 days of infarction. Forty four patients completed the study (19 on placebo and 25 on sulphinpyrazone). An additional ten patients commenced treatment within one day of infarction and were studied daily for one week. Platelet hyper-reactivity was demonstrable in all patients at presentation and persisted throughout the 6 months in the control group. This effect was reversed by sulphinpyrazone, the modification of reactivity being established by the third day of treatment. |
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Authors:
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M M Kubik; S G Richardson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Postgraduate medical journal Volume: 63 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-12-02 Completed Date: 1987-12-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 351-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Burton Road Hospital, West Midlands, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arachidonic Acid Arachidonic Acids / pharmacology Blood Platelets / drug effects, physiology* Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Myocardial Infarction / blood, drug therapy* Platelet Aggregation / drug effects Platelet Count Sulfinpyrazone / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 506-32-1/Arachidonic Acid; 57-96-5/Sulfinpyrazone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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