| A serial dilution microfluidic device for cytotoxicity assays. | |
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MedLine Citation:
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PMID: 17946141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel microfluidic device is presented which creates a linear serial dilution of two input fluid streams. This platform facilitates higher productivity as a component of a high throughput cytotoxicity testing strategy. A modeling solution is presented to create custom linear dilution schemes. The featured device creates a serial dilution of two solutions in the range of 1:9 through 9:1 across nine discrete dilutions. It has been validated to create a highly linear progression of dilutions with an R2 value of 0.9993. The device functions equivalently over a wide range of flow rates. The standard deviation of dilution values averages 0.76% over six flow rates spanning 0.5 to 16 microl min(-1). |
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Authors:
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Adrian T O'Neill; Nancy Monteiro-Riviere; Glenn M Walker |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 1 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2006 |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 2836-9 Citation Subset: IM |
Affiliation:
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Dept. of Biomed. Eng., North Carolina Univ., Chapel Hill, NC, USA. atoneill@ncsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Assay
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instrumentation*,
methods Cell Culture Techniques / instrumentation*, methods Computer-Aided Design* Equipment Design Equipment Failure Analysis Flow Cytometry / instrumentation*, methods Flow Injection Analysis / instrumentation*, methods Microfluidic Analytical Techniques / instrumentation* Toxicity Tests / instrumentation*, methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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