Document Detail


A sequential treatment algorithm for infants with stage 4s neuroblastoma and massive hepatomegaly.
MedLine Citation:
PMID:  22605456     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Infants with 4s neuroblastoma (NB) and massive hepatomegaly have a guarded prognosis and mortality approaches 30%. We report on eight patients with 4s NB and massive hepatomegaly treated with multiple modalities. One patient had spontaneous tumor regression. Three patients had progressive disease and responded to chemotherapy. Four patients progressed despite intravenous chemotherapy, of whom two died, and two were salvaged with hepatic intra-arterial chemoembolization. Treatment of infants with stage 4s NB with massive hepatomegaly should be individualized based on disease course. A sequential approach with observation, intravenous chemotherapy, and intra-arterial chemoembolization, may improve the outcome of these infants. Pediatr Blood Cancer 2012; 59: 182-184. © 2011 Wiley Periodicals, Inc.
Authors:
Michael Weintraub; Elisha Waldman; Benjamin Koplewitz; Allan I Bloom; Eitan Gross; Arnold I Freeman; Shoshana Revel-Vilk
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Publication Detail:
Type:  Journal Article     Date:  2011-05-16
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  59     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-05-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Pediatric Hematology-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. michaelw@hadassah.org.il.
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