| A sequential treatment algorithm for infants with stage 4s neuroblastoma and massive hepatomegaly. | |
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MedLine Citation:
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PMID: 22605456 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Infants with 4s neuroblastoma (NB) and massive hepatomegaly have a guarded prognosis and mortality approaches 30%. We report on eight patients with 4s NB and massive hepatomegaly treated with multiple modalities. One patient had spontaneous tumor regression. Three patients had progressive disease and responded to chemotherapy. Four patients progressed despite intravenous chemotherapy, of whom two died, and two were salvaged with hepatic intra-arterial chemoembolization. Treatment of infants with stage 4s NB with massive hepatomegaly should be individualized based on disease course. A sequential approach with observation, intravenous chemotherapy, and intra-arterial chemoembolization, may improve the outcome of these infants. Pediatr Blood Cancer 2012; 59: 182-184. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Michael Weintraub; Elisha Waldman; Benjamin Koplewitz; Allan I Bloom; Eitan Gross; Arnold I Freeman; Shoshana Revel-Vilk |
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Publication Detail:
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Type: Journal Article Date: 2011-05-16 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 59 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 182-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pediatric Hematology-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. michaelw@hadassah.org.il. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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