Document Detail

A sequential, prospective analysis of immunologic abnormalities and infection following severe thermal injury.
MedLine Citation:
PMID:  736659     Owner:  NLM     Status:  MEDLINE    
A sequential, prospective analysis of humoral and cellular immune function was performed on 20 burn patients with injuries involving >/=45% total body surface area. Infected patients had significantly worse neutrophil bactericidal activity against Staphylococcus aureus 502A than did noninfected patients. Chemotaxis of neutrophils correlated poorly with infection although chemotaxis was frequently abnormal. The opsonic index of serum was depressed early after the burn but returned to nearly normal values by the fourth to the fourteenth postburn day. There was no difference between infected and noninfected patients. Serum levels of IgG, properdin and C3, while initially low, remained within the normal range after the ninth postburn day in both groups. Factor B levels rose rapidly during the first three weeks after injury to more than double normal levels in many patients. Suggestive evidence for consumption of opsonic protein occurred with five of 19 episodes of bacteremia. The responsiveness of isolated lymphocytes to PHA was normal. However, patients' sera were shown to significantly inhibit the responsiveness of normal lymphocytes to PHA. Analysis of immunologic profiles for individual patients indicates that abnormalities of neutrophil function are the most important acquired defect predisposing patients to the development of bacteremia following major thermal injury; abnormalities of opsonic action play a secondary but important role.
J W Alexander; C K Ogle; J D Stinnett; B G Macmillan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  188     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  809-16     Citation Subset:  AIM; IM    
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MeSH Terms
Bacterial Infections / etiology*,  immunology
Blood Bactericidal Activity
Burns / complications*,  immunology
Chemotaxis, Leukocyte
Complement Factor B / metabolism
Immunity, Cellular
Immunoglobulin G / metabolism
Lymphocyte Activation
Neutrophils / immunology,  physiology
Prospective Studies
Serum Albumin / metabolism
Staphylococcus aureus
Reg. No./Substance:
0/Immunoglobulin G; 0/Serum Albumin; EC Factor B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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