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The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.
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MedLine Citation:
PMID:  2106568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Membrane IgM is expressed on the surface of B lymphocytes. It is not transported to the surface of transfected plasmacytoma or COS cells. Here, we show that mutation of four hydrophilic amino acids in the microm transmembrane is sufficient to overcome the intracellular retention of membrane IgM in non-B cells. This suggests that the B cell-specific IgM-associated proteins that have been postulated to assist the transport of membrane IgM to the cell surface (3) act either by forming a hydrophobic sheath that surrounds the microm transmembrane segment or by displacing an interaction with this segment that would otherwise cause retention. Experiments with a CD8/mu hybrid H chain indicate that the proteins that assist the transport of membrane IgM to the B cell surface at most need the mu CH4 and transmembrane/cytoplasmic portion for interaction.
Authors:
G T Williams; A R Venkitaraman; D J Gilmore; M S Neuberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  171     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-12     Completed Date:  1990-04-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  947-52     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
B-Lymphocytes / immunology*
Biological Transport
Humans
Immunoglobulin M / analysis*
Immunoglobulin mu-Chains / analysis*
Plasmacytoma / immunology
Receptors, Antigen, B-Cell / analysis*
Chemical
Reg. No./Substance:
0/Immunoglobulin M; 0/Immunoglobulin mu-Chains; 0/Receptors, Antigen, B-Cell
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 3 Year: 1990
Volume: 171 Issue: 3
First Page: 947 Last Page: 952
ID: 2187772
Publisher Id: 90171857
PubMed Id: 2106568

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface


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