Document Detail

A sequence from Drosophila DNA cross-hybridizing with a mouse class I H-2 gene: absence of relevant nucleic acid or amino acid sequence homology.
MedLine Citation:
PMID:  3006798     Owner:  NLM     Status:  MEDLINE    
Following serological data (1) showing cross-reactivity of drosophila surface antigens with anti-H-2 and mouse beta 2-microglobulin (beta 2-m) antisera, we have looked for homologous sequences in the drosophila genome by low stringency hybridization with mouse H-2 and beta 2-m probes. A 240 bp drosophila DNA segment cross-hybridizing with a H-2 probe, was isolated and sequenced. No homology at the nucleotide or amino acid levels was found with the mouse probe which was used, except for a perfectly matching 16-mer containing 11 G-C, which might be responsible for the cross-hybridization. Therefore, our present data do not support the existence of class I H-2 and/or beta 2-m related gene sequences in the drosophila genome.
A Israel; J L Becker; O Le Bail; P Kourilsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimie     Volume:  67     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-25     Completed Date:  1986-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  1225-9     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA / analysis
DNA Restriction Enzymes
Drosophila / genetics*
H-2 Antigens / genetics*
Major Histocompatibility Complex*
Nucleic Acid Hybridization
Protein Biosynthesis
beta 2-Microglobulin / genetics
Reg. No./Substance:
0/H-2 Antigens; 0/beta 2-Microglobulin; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes

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