| A sequel to the tale of p25/Cdk5 in neurodegeneration. | |
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MedLine Citation:
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PMID: 19081365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions. |
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Authors:
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Burcin Ikiz; Serge Przedborski |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Neuron Volume: 60 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-04-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 731-2 Citation Subset: IM |
Affiliation:
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Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclin-Dependent Kinase 5 / metabolism* Humans Models, Biological Nerve Degeneration / enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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5R01AG21617-05/AG/NIA NIH HHS; P01 NS11766/NS/NINDS NIH HHS; P50 NS38370-09/NS/NINDS NIH HHS; R21 NS062180/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.22/Cyclin-Dependent Kinase 5 |
| Comments/Corrections | |
Comment On:
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Neuron. 2008 Dec 10;60(5):803-17
[PMID:
19081376
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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