Document Detail

The separate diagnoses of Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL) in an individual patient may not signify a common clonal origin.
MedLine Citation:
PMID:  22659385     Owner:  NLM     Status:  Publisher    
HL and NHL have traditionally been considered as two distinct entities. However, there are rare reports of patients that over time develop both diseases. It remains unresolved whether the origin of the two diseases is from the same clone. In this study we attempted to retrospectively investigate the clinical and molecular aspects of patients who developed both lymphomas. The rearranged immunoglobulin heavy-chain variable region genes from both diagnoses were compared to each other. Twenty-six patients presented with both diagnoses. Twelve had HL as the primary disorder ("HL first" group) and the majority of these (75%) presented with aggressive lymphoma as the second lymphoma. In contrast, in the 11 patients where NHL was the primary disorder ("NHL first" group), this was usually (82%) of low grade histology. Three patients were diagnosed concurrently with both diseases. The average age at first diagnosis was higher (P=0.037) in the NHL first group (56.1 years) than in the HL first group (40 years). The average time between diagnoses was longer (P=0.026) in the HL first group (9 years) than in the NHL first group (5 years). For 11 patients, diagnostic samples were available for molecular analyses from both diagnoses, of HL and NHL. In 6 of these 11 patients, gene rearrangement studies were informative. No patient had same gene rearrangement identified in both diseases. It seems that the development of HL and NHL in one patient, at different time points, reflects, in many cases, separate biologic diseases.
C Ganzel; G Pogrebijsky; S Krichevsky; T Neuman; D Ben-Yehuda
Related Documents :
16307645 - Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients...
22449665 - Late-onset patients with sporadic amyotrophic lateral sclerosis in japan have a higher ...
22727705 - Alterations of mismatch negativity (mmn) in schizophrenia patients with auditory halluc...
21922215 - Late ophthalmological assessment of patients with subarachnoid hemorrhage and clipping ...
4002115 - Complement activation and clearance in acute illness and injury: evidence for c5a as a ...
12452305 - Pacemaker related endocarditis: analysis of seven cases.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-31
Journal Detail:
Title:  Experimental hematology     Volume:  -     ISSN:  1873-2399     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alteration of protein glycosylation in human hepatic stellate cells activated with transforming grow...
Next Document:  Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice.