| The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters. | |
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MedLine Citation:
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PMID: 1395563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization procedure, the results showed that all gallates are moderate to strong contact sensitizers: dodecyl (= lauryl) gallate was found to be the strongest. A characteristic correlation between side chain length and mean response was observed, giving a maximum of sensitization at a length of 12 carbon atoms (dodecyl gallate). A literature review revealed that the frequency of reports of allergic contact dermatitis from antioxidants of the gallate type has increased in the last 4 years. In most cases, the moderate sensitizer propyl gallate was the source of sensitization. |
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Authors:
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B M Hausen; W Beyer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Contact dermatitis Volume: 26 ISSN: 0105-1873 ISO Abbreviation: Contact Derm. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-11-02 Completed Date: 1992-11-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: DENMARK |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University Hospital, Hamburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dermatitis, Contact / etiology* Drug Hypersensitivity / etiology* Female Gallic Acid / adverse effects, analogs & derivatives*, immunology Guinea Pigs Humans Hypersensitivity, Delayed / chemically induced* Propyl Gallate / adverse effects*, immunology |
| Chemical | |
Reg. No./Substance:
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1034-01-1/octyl gallate; 1166-52-5/lauryl gallate; 121-79-9/Propyl Gallate; 149-91-7/Gallic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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