| The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin. | |
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MedLine Citation:
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PMID: 18581255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase expression strongly correlates with the grade of malignancy in glioma with inhibition illustrating a definite increase in chemosensitivity. This study was designed to investigate the effects of a green tea derivative, epigallocatechin-3-gallate (EGCG); together with either cisplatin or tamoxifen in glioma, and to investigate whether these effects are mediated through telomerase suppression. EGCG showed a significant cytotoxic effect on 1321N1 cells after 24 h and on U87-MG cells after 72 h (P < 0.001) without significantly affecting the normal astrocytes. Treatment with EGCG inhibited telomerase expression significantly (P < 0.01) and enhanced the effect of cisplatin and tamoxifen in both 1321N1 (P < 0.01) and U87-MG (P < 0.001) cells. EGCG, as a natural product has enormous potential to be an anti-cancer agent capable of enhancing tumour cell sensitivity to therapy. |
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Authors:
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Amal Shervington; Vidya Pawar; Sharad Menon; Dipti Thakkar; Rahima Patel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-26 |
Journal Detail:
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Title: Molecular biology reports Volume: 36 ISSN: 1573-4978 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-02 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1181-6 Citation Subset: IM |
Affiliation:
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Brain Tumour North West, Faculty of Science, University of Central Lancashire, Preston, UK. aashervington@uclan.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Catechin / analogs & derivatives, pharmacology* Cell Death / drug effects Cell Line, Tumor Cell Survival / drug effects Cisplatin / pharmacology* Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic / drug effects Glioma / pathology* Humans Tamoxifen / pharmacology* Telomerase / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 10540-29-1/Tamoxifen; 154-23-4/Catechin; 15663-27-1/Cisplatin; 989-51-5/epigallocatechin gallate; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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