| The sensitivity to hyperbaric oxygen of human diploid fibroblasts during ageing in vitro. | |
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MedLine Citation:
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PMID: 7354663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of hyperbaric oxygen on human diploid fibroblasts, WI-38, at various passages was examined. Their colony-forming ability deteriorates on exposure to hyperbaric oxygen. The cellular injury is not due to the high pressure per se, but to oxygen toxicity, since compressed nitrogen has no effect on the cells. When the cells beyond mid-40 population doublings (lifespan completed more than about 75%) are exposed to 50 atm of oxygen, there is a great decrease in the efficiency of the colony formation. A double exposure to 75 atm of oxygen inhibits the growth of the late passage cells more strongly than that of the early passage cells. These results suggest that the late passage cells are more sensitive to oxygen than the early passage cells. |
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Authors:
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S Honda; M Matsuo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 12 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-23 Completed Date: 1980-04-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Survival
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drug effects* Cells, Cultured Fibroblasts / drug effects*, physiology Humans Hyperbaric Oxygenation / adverse effects* Nitrogen / pharmacology |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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