Document Detail

The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children.
MedLine Citation:
PMID:  16469676     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Multichannel intraluminal impedance (MII) has been incorporated into gastroesophageal reflux evaluations in children despite a lack of evidence comparing it to the gold standard pH probe. The aim of this study was to compare these two technologies. METHODS: Twenty-five consecutive, untreated children undergoing pH-MII recording were studied. Sensitivities for the pH probe and MII were defined as: (acid+pH-only episodes)/(acid+non-acid+pH-only episodes) and (acid+non-acid episodes)/(acid+non-acid+pH-only episodes), respectively. Sensitivities were compared using paired t testing. After the analysis was performed, the pH-MII tracings of 25 age-matched children taking acid suppression therapy were compared and sensitivity calculations were performed. RESULTS: In untreated patients, 1845 reflux episodes were detected, and 1702 were detected in treated patients. The mean sensitivities of pH probe and MII in untreated patients were 80.6 +/- 18.2% and 76.1 +/- 13.5%, respectively (P = .41). The mean sensitivities of pH probe and MII in treated patients were 47.2 +/- 36.0% and 80.3 +/- 21.1%, respectively (P = .005). Twenty-five percent of reflux episodes were pH-only episodes. There were no differences in the mean number of acid or non-acid reflux episodes in patients with normal and abnormal pH probe studies. Instead, there were significantly more pH-only episodes in patients with abnormal probe studies. CONCLUSIONS: The sensitivity of MII equals that of the pH probe in untreated patients but is superior to the pH probe in treated patients. pH-only episodes are numerous in pediatrics and should be included in pH-MII analyses.
Rachel Rosen; Candace Lord; Samuel Nurko
Related Documents :
20528616 - Monoolein cubic phase containing acidic proteinoid: ph-dependent release.
8796426 - Evaluation of citric acid and gdl in the recovery at different ph levels of clostridium...
16286476 - Alkaline-shifted pho sensitivity of ae2c1-mediated anion exchange reveals novel regulat...
1746896 - Hypoxia and acidity increase the cytotoxicity of mitomycin c and carboquone to human tu...
9642766 - Sensing biological effectors through the response of bridged nucleic acids and polynucl...
9126386 - Measurement of 15n/14n isotopic composition in individual plasma free amino acids of hu...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  4     ISSN:  1542-3565     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology and Nutrition, Children's Hospital-Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electric Impedance
Gastric Acidity Determination
Gastroesophageal Reflux / diagnosis*,  drug therapy
Hydrogen-Ion Concentration
Monitoring, Physiologic
Prospective Studies
Sensitivity and Specificity
Grant Support
Comment In:
Clin Gastroenterol Hepatol. 2006 Sep;4(9):1184; author reply 1185   [PMID:  16962511 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Advances and perspectives in the genetics of inflammatory bowel diseases.
Next Document:  Frozen section analysis of esophageal endoscopic mucosal resection specimens in the real-time manage...