| The sensitivity of interferon-gamma release assays is not compromised in tuberculosis patients with diabetes. | |
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MedLine Citation:
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PMID: 21219678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DESIGN: the sensitivity of the IGRAs QuantiFERON®-TB Gold (QFT-G) and T-SPOT®.TB was evaluated among specimens from newly diagnosed adults with microbiologically confirmed TB with and without diabetes. We also evaluated the association between QFT-G results and diabetes-associated conditions (dyslipidemia, obesity). RESULTS: QFT-G sensitivity was 70% among TB patients. Patients with diabetes, chronic hyperglycemia or overweight/obesity were more than twice as likely to have positive test results in multivariate models (P < 0.05). Low high-density lipoprotein cholesterol or high triglycerides were not associated with assay results. In a separate group of TB patients (n = 43), T-SPOT.TB was 93% sensitive, with similar performance in patients with and without diabetes. CONCLUSION: IGRA sensitivity is not compromised by diabetes in TB patients. Accordingly, IGRAs may also be suitable for diagnosing TB infection in diabetes patients, which is required to assess TB risk. |
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Authors:
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M C Walsh; A J Camerlin; R Miles; P Pino; P Martinez; F Mora-Guzmán; J G Crespo-Solis; S P Fisher-Hoch; J B McCormick; B I Restrepo |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 15 ISSN: 1815-7920 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: 2011-04-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
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Languages: eng Pagination: 179-84, i-iii Citation Subset: IM |
Affiliation:
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Division of Epidemiology, School of Public Health in Brownsville, University of Texas Health Science Center at Houston, Brownsville, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Chi-Square Distribution Diabetes Mellitus, Type 2 / immunology* Dyslipidemias / immunology Female Humans Interferon-gamma / metabolism* Logistic Models Lymphocytes / immunology, microbiology* Male Middle Aged Mycobacterium tuberculosis / immunology* Obesity / immunology Predictive Value of Tests Prospective Studies Reagent Kits, Diagnostic* Sensitivity and Specificity Tuberculosis / diagnosis*, immunology, microbiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1 R21 AI064297-01-A1/AI/NIAID NIH HHS; 1U54RR023417-01/RR/NCRR NIH HHS; P20 MD000170-04/MD/NCMHD NIH HHS; P20 MD000170-04/MD/NCMHD NIH HHS; R21 AI064297-01A1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reagent Kits, Diagnostic; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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