Document Detail


A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations.
MedLine Citation:
PMID:  17878112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new, simple and sensitive spectrophotometric method for the determination of some sulfonamide drugs has been developed. The method is based on the diazotization of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole, and their coupling with 8-hydroxyquinoline in alkaline media to yield red coloured products with absorption maxima at 500 nm. Beer's law is obeyed from 0.1-7.0 microg mL-1. The limits of quantification and limits of detection were 0.11-0.18 and 0.03-0.05 microg mL-1, respectively. Intraday precision (RSD 0.1-0.5%) and accuracy (recovery 97.3--100.8%) of the developed method were evaluated. No interference was observed from common adjuvants. The method has been successfully applied to the assay of sulpha drug in pharmaceutical formulations.
Authors:
Padmarajaiah Nagaraja; Shailendra D Naik; Ashwinee Kumar Shrestha; Anantharaman Shivakumar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmaceutica (Zagreb, Croatia)     Volume:  57     ISSN:  1330-0075     ISO Abbreviation:  Acta Pharm     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303678     Medline TA:  Acta Pharm     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  333-42     Citation Subset:  IM    
Affiliation:
Department of Studies in Chemistry, University of Mysore, Manasagangothri Mysore-570006, India. nagarajap58@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Azo Compounds / chemistry
Color
Excipients / chemistry
Molecular Structure
Oxyquinoline / chemistry
Pharmaceutical Preparations / chemistry*
Reproducibility of Results
Spectrophotometry / methods*
Spectrophotometry, Ultraviolet / methods
Sulfonamides / analysis*,  chemistry
Technology, Pharmaceutical / instrumentation,  methods
Chemical
Reg. No./Substance:
0/Azo Compounds; 0/Excipients; 0/Pharmaceutical Preparations; 0/Sulfonamides; 148-24-3/Oxyquinoline

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