| A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. | |
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MedLine Citation:
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PMID: 17878112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new, simple and sensitive spectrophotometric method for the determination of some sulfonamide drugs has been developed. The method is based on the diazotization of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole, and their coupling with 8-hydroxyquinoline in alkaline media to yield red coloured products with absorption maxima at 500 nm. Beer's law is obeyed from 0.1-7.0 microg mL-1. The limits of quantification and limits of detection were 0.11-0.18 and 0.03-0.05 microg mL-1, respectively. Intraday precision (RSD 0.1-0.5%) and accuracy (recovery 97.3--100.8%) of the developed method were evaluated. No interference was observed from common adjuvants. The method has been successfully applied to the assay of sulpha drug in pharmaceutical formulations. |
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Authors:
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Padmarajaiah Nagaraja; Shailendra D Naik; Ashwinee Kumar Shrestha; Anantharaman Shivakumar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmaceutica (Zagreb, Croatia) Volume: 57 ISSN: 1330-0075 ISO Abbreviation: Acta Pharm Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-19 Completed Date: 2008-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303678 Medline TA: Acta Pharm Country: Croatia |
Other Details:
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Languages: eng Pagination: 333-42 Citation Subset: IM |
Affiliation:
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Department of Studies in Chemistry, University of Mysore, Manasagangothri Mysore-570006, India. nagarajap58@yahoo.co.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Azo Compounds
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chemistry Color Excipients / chemistry Molecular Structure Oxyquinoline / chemistry Pharmaceutical Preparations / chemistry* Reproducibility of Results Spectrophotometry / methods* Spectrophotometry, Ultraviolet / methods Sulfonamides / analysis*, chemistry Technology, Pharmaceutical / instrumentation, methods |
| Chemical | |
Reg. No./Substance:
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0/Azo Compounds; 0/Excipients; 0/Pharmaceutical Preparations; 0/Sulfonamides; 148-24-3/Oxyquinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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