Document Detail


A sensitive assay for mutagenic activity of N-nitrosamines and its use for detection of modulators of the mutagenicity.
MedLine Citation:
PMID:  6754597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By carrying out the pre-incubation of bacteria with N-nitrosamines under acidic conditions, the mutagenicity of N-nitrosodimethylamine on Salmonella TA100 and E. coli WP2 try, hcr was detected with increased sensitivity, compared to usual assays in neutral buffers. Using this modified assay system, compounds have been screened for their modulating effects on N-nitrosamine-mediated mutagenesis and the following were found to be inhibitors: cysteine, cysteamine, bisulfite, n-propylamine, n-butylamine, n-hexylamine, n-octylamine, n-nonylamine, serotonine, tryptamine, epinephrine, norepinephrine and oleic acid. The mechanisms of inhibition are discussed.
Authors:
T Negishi; Y Ohara; H Hayatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IARC scientific publications     Volume:  -     ISSN:  0300-5038     ISO Abbreviation:  IARC Sci. Publ.     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8009542     Medline TA:  IARC Sci Publ     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  685-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amines / pharmacology
Escherichia coli / drug effects
Fatty Acids / pharmacology
Mutagenicity Tests / methods*
Nitrosamines / toxicity*
Salmonella typhimurium / drug effects
Sulfites / pharmacology
Chemical
Reg. No./Substance:
0/Amines; 0/Fatty Acids; 0/Nitrosamines; 0/Sulfites

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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