Document Detail

The sense of smell in systemic lupus erythematosus.
MedLine Citation:
PMID:  19404932     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the olfactory functions in systemic lupus erythematosus (SLE) patients compared with age- and sex-matched healthy controls, and to examine the association between the sense of smell and disease activity and central nervous system (CNS) involvement. METHODS: Olfactory functions in 50 SLE patients and 50 age- and sex-matched controls were evaluated using the Sniffin' Sticks test, the 3 stages of which are threshold, discrimination, and identification (TDI) of different odors. TDI scores were analyzed according to SLE disease activity and CNS involvement. RESULTS: In both the SLE and control groups, smell deficit correlated with male sex and older age. A decrease in the sense of smell was observed in SLE patients (46%) and controls (25%) (P<or=0.02), while loss of smell (anosmia) was documented only in SLE patients (10%). Total TDI scores and individual stages of smell correlated with SLE Disease Activity Index (P<0.001) and CNS manifestations (P<0.03). CONCLUSION: Our findings suggest that there is a decrease in the sense of smell in SLE patients compared with healthy subjects and that the decrease in the sense of smell among SLE patients correlates with disease activity and CNS involvement.
Netta Shoenfeld; Nancy Agmon-Levin; Iveta Flitman-Katzevman; Daphna Paran; Bat-sheva Porat Katz; Shaye Kivity; Pnina Langevitz; Gisele Zandman-Goddard; Yehuda Shoenfeld
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  60     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1484-7     Citation Subset:  AIM; IM    
Department of Medicine B, Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Age Factors
Differential Threshold
Lupus Erythematosus, Systemic / physiopathology*
Lupus Vasculitis, Central Nervous System / physiopathology
Sex Factors
Smell / physiology*

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