Document Detail


The seminiferous epithelium cycle length in the black tufted-ear marmoset (Callithrix penicillata) is similar to humans.
MedLine Citation:
PMID:  16319285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marmosets are New World small primates phylogenetically close to humans and are commonly used in biomedical research. Although the reproductive biology of the common marmoset Callithrix jacchus is fairly well investigated, there are few data available for testis function for its close relative, Callithrix penicillata. In this regard, the present study was performed to investigate testis structure, spermatogenic cycle length, and spermatogenic and Sertoli cell efficiencies in eight captive C. penicillata. These animals received (3)H-thymidine injections and had their testes perfused-fixed with glutaraldehyde and embedded in plastic at different time periods after (3)H-thymidine injections, for histomorphometric and autoradiographic evaluation. The analysis of the different germ cell associations showed that two or more stages were observed in about 30% of the seminiferous tubule cross sections investigated. The values found for spermatogenic cycle length and for total duration of spermatogenesis in the marmoset C. penicillata, 15.4 and 69.3 days respectively, were very close to those cited in the literature for humans. However, the results observed for Sertoli cell efficiency (number of round spermatids per Sertoli cell; 8:1) and spermatogenic efficiency (daily sperm production per gram of testis; 18.4 million) were substantially higher than those observed for humans. The results found in the present investigation suggest that the black tufted-ear marmoset C. penicillata might represent an alternative and useful experimental model to perform comparative studies regarding the spermatogenic process, particularly in investigations related to the expansion of spermatogonial stem cells and the establishment of spermatogenic waves.
Authors:
Marcelo C Leal; Luiz R França
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-30
Journal Detail:
Title:  Biology of reproduction     Volume:  74     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-24     Citation Subset:  IM    
Affiliation:
Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte MG, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biometry
Callithrix / anatomy & histology,  physiology*
Humans
Male
Seminiferous Epithelium / cytology,  physiology*
Spermatogenesis / physiology*
Testis / anatomy & histology,  cytology

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